It is estimated that in the US alone, over 2 million people will be affected by cancer with 400,000 deaths per year. Research in our laboratories includes the following areas: 1) Investigating ways to limit metastasis in prostate and breast cancer; 2) Regulation of gene expression, gene silencing and telomere homeostasis in cancer cells; 3) Regulation of growth and apoptosis and understanding defects in genes that alter these processes; 4) Molecular studies of tumors in the nervous system and how cells communicate to regulate cell growth; 5) The rational design of novel anticancer therapeutic agents that target DNA and kill tumor cells, and; 6) New diagnostic screens that detect cancer at an early stage when tumor cells are in a primary tissue of origin.