Information about Research Areas at UCF Burnett School of Biomedical Sciences:
http://www.youtube.com/ucf#p/u/0/FhIus-3E79c

Interested in applying for graduate studies in Dr. Muller’s laboratory?  We have an exciting array of projects (research projects).  For more information regarding UCF and the application process, prospective graduate students may go to this link:
www.graduate.ucf.edu. You may also contact us directly at  biomoldoc@mail.ucf.edu

Dr. Mark T. Muller, Ph.D.
Professor of Molecular Biology and Microbiology
University of Central Florida
College of Medicine
Biomolecular Research Annex
12722 Research Parkway
Orlando, FL 32826-3227

Office:   407-882-2268
Lab:      407-882-2267
Fax:      407-384-2062

Mark.Muller@ucf.edu

Hello and welcome to the home page for the Dr. Mark Muller’s Laboratory of Cancer Research at the University of Central Florida in beautiful Orlando, Florida.  The laboratory is an established group of researchers working on the molecular biology of cancer and gene regulation.  Specific research focus areas include studies on DNA topoisomerases, gene silencing, DNA repair and telomerase regulation. For details go to research.

Latest News from the lab:
Dr. Muller returned from an 8 month sabbatical in Naples, Italy working with collaborators on gene silencing mechanisms following repair.  This work was recently published (see GADD45 paper in Nuc. Acid. Res. below).

Welcome Dr. Orde Munro, from the University of Kwazulu-Natal (Pietermaritzburg, South Africa).  Dr. Munro is an inorganic chemist and his group has synthesized a large number of new gold compounds that target pro- and eukaryotic topoisomerases.  He is here on a Fullbright Fellowship for 2010-11.

Congratulations to Vidusha Cyril, who just defended here thesis in November 2011. 

Latest Publications:

GADD45a inhibition of DNMT1 dependent DNA methylation during homology directed DNA repair Bongyong Lee; Annalisa Morano; Antonio Porcellini; Mark T. Muller Nucleic Acids Research 2011; doi: 10.1093/nar/gkr1115  
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 A Solid Phase Assay for Topoisomerase I Interfacial Poisons and Catalytic Inhibitors. Cyril, V. and Muller, M.    Analytical Biochemistry 42: 607-615 (2012)
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Topoisomerase II mediated damage and repair by HR/NHEJ mechanisms. Goldstein, E., and Muller, M.T. (2011).   URJ 5:51-67.
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DNA methyltransferase 1-associated protein (DMAP1) is a co-repressor that stimulates DNA methylation globally and locally at sites of double strand DNA break repair.  Lee, G., and Muller, M.   J. Biol. Chem.  285: 37630-37640. 
PDF.

Prostate cancer cell surface-associated Keratin 8 and its implications for enhanced plasmin activity. Kuchma, M., Kim, J., Muller, M., Arlen, P. (2012) Protein J. 31:195 PDF

Loss of CCDC6, the first identified RET partner gene in papillary thyroid carcinoma,affects gH2AX levels and accelerates mitotic entry upon DNA damage Merolla,F. Luise,C., Muller, M., Pacelli,R., Fusco,A. and Celetti,A. (2012) .  PLoS One PONE-D-12-00962R2 (In press to be published May, 2012).