Kang, M.R, Muller, M.T. and In Kwon Chung. (2004) Telomeric DNA Damage by Topoisomerase I: A possible mechanism for cell killing by camptothecin. J. Biol. Chem., 279: 12535 – 12541 PDF
Ju, R., Muller, M.T. (2003). Histone Deactylase Inhibitors Activate p21 through ATM. Cancer Research 63:2891-2897. PDF
Mao, Y., Mehl, I., and Muller, M.T. (2002) Nuclear and Nucleolar Localization by the N-terminal Domain of DNA Topoisomerase I. Proc. Natl Acad. Sci., USA. 99: 1235-1240 PDF
Ulukan, H. Muller, M.T., Swaan, P.W. (2001) Down Regulation of topoisomerase I in differentiating human instestinal epithelial cells. International Journal of Cancer. 94:200-9 PDF
Ju, R., Mao, Y, glick, M., Muller, M, Snyder, R. (2001) Catalytic inhibition of DNA topoisomerase IIa by sodium azide. Toxicology Letters, 121:119-126. PDF
Mao, Y. , Okada, S., Chang, L. and Muller, M.T. (2000) p53 Dependence of Topoisomerase I Recruitment in vivo Cancer Research 60: 4538-4543 PDF
Liu, K., Wang, Y., Cantemir, C and Muller, M.T., (2003). Endogenous assays of DNA methyltransferases: Evidence for differential activity of DMT1, DNMT2, DNMT3 in mammalian cells in vivo. Molec. Cell. Biol. 23: 2709-2719 PDF
Kang, M.R, Muller, M.T. and In Kwon Chung. (2004) Telomeric DNA Damage by Topoisomerase I: A possible mechanism for cell killing by camptothecin. J. Biol. Chem., Mar 2004; 279: 12535 – 12541 PDF
Lee, G.E., Yu, E., Cho, C., Lee, J., Muller, M., Chung, I. (2004). DNA-PKcs interacting protein KIP binds telomerase through interaction with hTERT. J. Biol. Chem. 279: 34750-5 PDF
Kim, J, Park S., Kang, M, Oh S., Lee, T and Muller, M and Chung, I. (2005) Ubiquitin ligase MKRN1 modulates telomere length homeostasis through proteolysis of hTERT. Genes and Development 19:776-781. PDF
Guisheng Zhang, Jie Shen, Hao Cheng, Lizhi Zhu, Lanyan Fang, Sanzhong Luo, Mark T. Muller, Gun Eui Lee, Lijun Wei, Yuguo Du, Duxin Sun, and Peng George Wang Syntheses and Biological Activities of Rebeccamycin Analogues with Uncommon Sugars. (2005) J. Med. Chem.: 48:2600 - 2611. PDF.
Cuozzo, C., Angrisano, T., Porcellini, A., Morano, A., Messina, S., Santillo, R., Chiariotti, L., Iuliano, R., Fusco, A., Gottesman, M.E., Muller, M.T., Lee, B., Avvedimento, E.V. Homology Directed Repair and DNA Methylation. PLoS Genetics 3: 1144-1162 (2007)
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Commentary on above paper in Nature Reviews Genetics 8: 492 (2007)
Lee, B. and Muller, M. SUMOylation enhances DNA methyltransferase 1 activity. Biochemical Journal 421: 449-461 (2009). PDF
Alvarez, S.M., Lee, B., and Muller, M. GADD45a modulation of DNA methylation induced by DNA damage during homologous recombination. Revista Ingenieria Biomedica 3: 51-58 (2009). PDF
Leventhal, D. and Muller, M. (2010) Characterization of cytokeratin 8 in cancer. University of Central Florida Undergraduate Research Journal 4: 23-33.
Salvatico, J., and Muller, M. (2010) Makorin1 is a Ubiquitin Ligase Induced during Differrentiation Results in degradation of hTERT. Molec. Cell. Biochem 342:241-250.
http://www.springerlink.com/content/j150x70116740824/
Lee, G, Kim, J., Taylor, M, Muller, M. (2010) DNA Methyltransferase 1-associated Protein (DMAP1) Is a Co-repressor That Stimulates DNA Methylation Globally and Locally at Sites of Double Strand Break Repair. J. Biolog. Chem. 285:37360-40
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Goldstein, E. and Muller, M. (2011) Analysis of Repair of Topoisomerase II DNA Damage University of Central Florida Undergraduate Research Journal 5: 51-67.
http://www.urj.ucf.edu/docs/goldstein.pdf
Lee, B.; Morano, A.; Porcellini, A. Muller, M. (2011) GADD45a inhibition of DNMT1 dependent DNA methylation during homology directed DNA repair (2011) Nucleic Acids Research 2011; doi: 10.1093/nar/gkr1115
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In another project, we have discovered a new mechanism for telomerase and telomere reguation. We have cloned a novel Ubiquitin ligase, MKRN1, that modulates telomere length homeostasis through proteolysis of hTERT. The paper was published in Genes and Development 19:776-781) and was mentioned on the cover of the journal. A series of press releases on our findings are shown on the left. A follow up paper on this work has recently been published.
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Interested in applying for graduate studies in Dr. Muller’s laboratory? We have an exciting array of projects (research projects). For more information regarding UCF and the application process, prospective graduate students may go to this link:
www.graduate.ucf.edu. You may also contact us directly at biomoldoc@mail.ucf.edu
Dr. Mark T. Muller, Ph.D.
Professor of Molecular Biology and Microbiology
University of Central Florida
College of Medicine
Biomolecular Research Annex
12722 Research Parkway
Orlando, FL 32826-3227
Office: 407-882-2268
Lab: 407-882-2267
Fax: 407-384-2062
mtmuller@mail.ucf.edu
Information about Research Areas at UCF Burnett School of Biomedical Sciences:
http://www.youtube.com/ucf#p/u/0/FhIus-3E79c